Watch Carefully (1)modafinil will improve the level or impact of citalopram by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Citalopram twenty mg/working day is the most advisable dose for people using CYP2C19 inhibitors as a result of hazard of QT prolongation.

Renal Impairment: Modafinil needs to be made use of with warning in people with significant renal impairment. Nevertheless, no recommendations for renal dosing exist.

Clopidogrel efficacy may be lessened by medication that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is totally resulting from an Energetic metabolite. Clopidogrel is metabolized to this Energetic metabolite partly by CYP2C19. .

Doses approximately 400 mg/working day, offered as a single dose, are actually very well tolerated, but there is no constant proof this dose confers extra reward over and above that with the two hundred mg/day dose

Adderall is likewise a great deal more very likely than modafinil to bring about dependancy and dependence and withdrawal symptoms on discontinuation, As well as more side effects, without having improving IQ.

Narcolepsy: Very first-line cure; Modafinil is used to deal with the daytime exhaustion affiliated with narcolepsy, and it has not been shown to further improve signs and symptoms of cataplexy.

Neither modafinil nor Adderall really should be mixed with Alcoholic beverages. Regardless that modafinil and Adderall are each stimulating and Alcoholic beverages is actually a depressant, having them together doesn't cancel one another a single out; alternatively it sends the Mind mixed messages.

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modafinil will minimize the extent or impact of iobenguane I 131 by Other (see remark). Keep away from or Use Alternate Drug. Depending on the system of action of iobenguane, medication that minimize catecholamine uptake or that deplete catecholamine outlets might interfere with iobenguane uptake into cells, and therefore, reduce iobenguane efficacy.

etravirine will lower the extent or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.

It's Obviously a probability that modafinil could directly act on enzymes from the Mind’s totally free-radical scavenging method (eg, glutathione peroxidase or superoxide dismutase) to straight minimize free of charge-radical stages. Simply because, reactive oxygen species feed back positively get more info within the mitochondrion to scale back ATP generation And maybe enrich free radical output (Echtay et al 2002; Brookes et al 2004), this type of system could also account for modafinil’s capacity to enhance the cortical creatine-phosphocreatine pool (Pierard et al 1995).

Keep away from or substitute A further drug for these medicines when attainable. Examine for loss of therapeutic result if medication need to be coadministered.

Drugs which have step therapy connected to Every prescription. This restriction ordinarily needs that sure requirements be fulfilled before acceptance for the prescription.

tazemetostat will lower the extent or outcome of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.